Description
An L-type calcium channel inhibitor; induces relaxation of precontracted isolated porcine coronary artery segments (EC50 = 0.15 nM); selective for L-type calcium channels over N-, R-, and P/Q-type channels at 10 µM, as well as the T-type Cav3.2 channel (IC50 = 6.8 µM); inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 33.9 and 3,981 nM, respectively); decreases mean arterial blood pressure and total peripheral resistance in a rabbit model of hypertension induced by renal artery ligation at 30 and 100 nmol/kg